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Strong Support

When obese men fast for 3 days, blocking their growth hormone lowers the amount of sugar their bodies produce.

41
Pro
0
Against

Evidence from Studies

Supporting (1)

41

Community contributions welcome

41

Substrate Metabolism and Insulin Sensitivity During Fasting in Obese Human Subjects: Impact of GH Blockade

Randomized Controlled Trial
Human
2017 Apr 1

The study gave obese men a drug (pegvisomant) that blocks growth hormone during a 72-hour fast and found that this significantly reduced the liver's glucose production, directly confirming the claim.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Substrate Metabolism and Insulin Sensitivity During Fasting in Obese Human Subjects: Impact of GH Blockade

Score: 41
DOI: 10.1210/jc.2016-3835

Similar Assertions

When men with obesity fast for 3 days while also blocking growth hormone, their bodies become better at using insulin again.

41
0
89%

When obese men fast, blocking growth hormone makes insulin better at reducing fat-related molecules in their blood.

41
0
87%

When obese men go without food for 3 days, their bodies make more growth hormone.

41
0
82%

Growth hormone helps control how the body breaks down and uses energy from food, and it affects how well the body responds to insulin—especially in people who are obese.

41
0
73%

When people with low growth hormone take their hormone while fasting, their blood sugar goes up a little, but their body doesn’t use more or less glucose overall—so it’s just keeping sugar available without changing how it’s burned.

37
0
71%