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Strong Support

When obese men fast, blocking growth hormone makes insulin better at reducing fat-related molecules in their blood.

41
Pro
0
Against

Evidence from Studies

Supporting (1)

41

Community contributions welcome

41

Substrate Metabolism and Insulin Sensitivity During Fasting in Obese Human Subjects: Impact of GH Blockade

Randomized Controlled Trial
Human
2017 Apr 1

The study gave obese men a drug (pegvisomant) that blocks growth hormone during fasting, then tested how insulin suppresses fat-related molecules. The results showed that blocking growth hormone made insulin better at suppressing fat molecules, exactly matching the claim.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Substrate Metabolism and Insulin Sensitivity During Fasting in Obese Human Subjects: Impact of GH Blockade

Score: 41
DOI: 10.1210/jc.2016-3835

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When obese men fast for 3 days, blocking their growth hormone lowers the amount of sugar their bodies produce.

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Growth hormone helps control how the body breaks down and uses energy from food, and it affects how well the body responds to insulin—especially in people who are obese.

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