When carbohydrates are consumed, the body releases insulin, which lowers the rate at which muscle proteins are broken down and slightly raises the rate at which new muscle proteins are made.
Mechanism
Synthesis from 2 studies
Eating carbs makes insulin rise, which helps slow down muscle breakdown, but only if you also have enough protein. If you already have plenty of amino acids from protein, adding more carbs doesn’t help much more — so the real driver is protein, not carbs.
Most probable mechanism
When you eat carbs, your body releases insulin, which tells muscle cells to slow down the process that breaks down proteins. This helps keep more muscle intact, and may also slightly help build new muscle, but the main effect is stopping the breakdown.
Carbohydrate ingestion elevates blood insulin levels
Elevated insulin signaling reduces the activity of the ubiquitin-proteasome system in skeletal muscle
Reduced ubiquitin-proteasome activity decreases the rate of muscle protein degradation
Insulin modestly enhances activation of mTORC1 signaling, increasing translation initiation and muscle protein synthesis
Less supported by current evidence, but not ruled out
Even without insulin, having more amino acids from food can slow down muscle breakdown, which might explain why adding carbs doesn't always help more than just eating protein.
Essential amino acids directly inhibit proteolytic pathways in muscle independent of insulin
Carbohydrate-induced insulin elevation does not further suppress breakdown beyond the effect of amino acids alone
Evidence from Studies
Supporting (1)
Community contributions welcome
Effect of carbohydrate intake on net muscle protein synthesis during recovery from resistance exercise.
Contradicting (1)
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Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise
Gold Standard Evidence Needed
According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.