When hens are given omega-3 supplements during egg production, their chicks have lower levels of catalase enzyme in the heart compared to chicks from hens fed low omega-3 diets. Levels of other...
Mechanism
Synthesis from 1 study
Omega-3 fats from the mother get into the chick's heart and change the chemical signals there. This change specifically turns down one enzyme, catalase, but doesn't touch any other antioxidants or fats in the heart.
Most probable mechanism
When a mother consumes more omega-3 fats, those fats end up in her eggs. When chicks hatch, those omega-3 fats get built into the fatty membranes of their heart cells. This changes the type of signaling molecules the heart produces, which directly turns down the activity of one specific enzyme called catalase, without affecting other antioxidant enzymes or fat levels in the heart.
Maternal dietary omega-3 fatty acids increase the concentration of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in egg yolk lipids
Egg-derived omega-3 fatty acids are incorporated into cardiac phospholipid membranes of hatched chicks
Increased cardiac EPA competes with arachidonic acid for binding to cyclooxygenase enzymes, shifting eicosanoid production toward thromboxane A3 and away from prostaglandin E2
Reduced prostaglandin E2 signaling alters intracellular redox regulation, specifically suppressing catalase enzyme activity without affecting glutathione peroxidase, superoxide dismutase, or total glutathione levels
Evidence from Studies
Supporting (1)
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Contradicting (0)
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