Continuing tesamorelin for a full year helps HIV patients with belly fat lose nearly 18% of their dangerous internal belly fat, with no loss of benefit over time.

Scientific Claim

Tesamorelin reduces visceral adipose tissue by approximately 18% in HIV-infected patients with central fat accumulation after 12 months of continuous treatment (P < 0.001).

Original Statement

“VAT was reduced by approximately 18% (P < 0.001) in patients continuing tesamorelin for 12 months.”

From study:Unknown Title

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

The study is a randomized controlled trial with a control group, which allows for causal inference. The verb 'reduces' is appropriate for this design.

Evidence from Studies

Supporting (1)

Unknown Title

Randomized Controlled Trial

Human

This study found that a drug called tesamorelin helped HIV patients lose about 18% of their dangerous belly fat after a year of daily shots, and the results were strong and reliable.

Contradicting (0)

No contradicting evidence found

Source Study

Unknown Title

Score: 81

DOI: 10.1097/QAI.0b013e3181cbdaff

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