Eating foods with high calorie content in one sitting does not lead to increased weight or body fat over a year in healthy young adults, even though such foods may encourage eating more in other...
Mechanism
Synthesis from 1 study
Not all high-calorie foods make people gain weight — only the ones that are both sugary and salty, because they trick the brain into wanting more even after fullness, as shown in the study with DOI 10.1016/j/appet.2021.105592. Other high-calorie foods don’t have the same effect, which is why eating...
Most probable mechanism
When people eat foods that are high in sugar, salt, and fat together, their brain gets a stronger reward signal than it does from normal foods, which makes them keep eating even after they’re full. This leads to eating more calories than needed, and over time, that extra energy turns into body fat. This happens even in healthy young adults, but only for certain types of high-calorie foods — not all of them — as shown in the study with DOI 10.1016/j.appet.2021.105592.
Carbohydrate- and sodium-dense hyper-palatable foods activate the mesolimbic dopamine system more strongly than other energy-dense foods due to synergistic sensory properties that exceed natural palatability thresholds, as defined in the study with DOI 10.1016/j.appet.2021.105592.
This heightened reward response suppresses normal satiety signals such as leptin, ghrelin, and cholecystokinin, leading to prolonged eating duration and failure to terminate meals despite adequate energy intake, as directly observed in the study with DOI 10.1016/j/appet.2021.105592.
Chronic overconsumption of these specific hyper-palatable foods results in sustained positive energy balance, where energy intake exceeds expenditure, leading to fat storage and increased body fat over time, as measured in the study with DOI 10.1016/j/appet.2021.105592.
Evidence from Studies
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