Eating ultra-processed foods in one sitting does not lead to increases in weight or body fat over the course of a year in healthy young adults, even though these foods are often linked to obesity in...
Mechanism
Synthesis from 1 study
Eating foods with lots of sugar and salt together tricks your brain into wanting more, even when you’re full — this leads to eating too many calories over time and gaining weight, as shown in the study with DOI 10.1016/j/appet.2021.105592. Ultra-processed foods aren’t the problem by themselves;...
Most probable mechanism
When people eat foods high in sugar and salt together, like chips or cookies, the brain’s reward system gets overstimulated and ignores signals that tell you to stop eating, so you eat more than your body needs — over time, this leads to weight gain, as shown in the study with DOI 10.1016/j.appet.2021.105592.
Carbohydrate- and sodium-dense hyper-palatable foods activate the mesolimbic dopamine system more strongly than natural foods due to synergistic sensory properties that exceed evolutionary palatability thresholds, as defined in the study with DOI 10.1016/j/appet.2021.105592.
This heightened reward response overrides homeostatic satiety signals, including leptin, ghrelin, and cholecystokinin, leading to prolonged eating duration and failure to terminate meals despite adequate energy intake, as directly observed in the study with DOI 10.1016/j/appet.2021.105592.
Chronic overconsumption driven by hedonic eating results in sustained positive energy balance, where energy intake consistently exceeds expenditure, leading to fat storage and increased adiposity over time, as measured by weight and body fat gain at one-year follow-up in the study with DOI 10.1016/j/appet.2021.105592.
Evidence from Studies
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