Excessive dietary fructose consumption promotes hepatic de novo lipogenesis, elevates circulating triglycerides and very-low-density lipoprotein, and induces systemic inflammation, thereby increasing the risk of cardiovascular disease.

Study: Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial.

This study found that drinking sodas with fructose or table sugar (which contains fructose) makes the liver produce more fat, while drinking soda with plain sugar (glucose) doesn’t. Since excess liver fat leads to higher blood fats linked to heart disease, this supports the idea that too much fructose is bad for your heart.

Study: John Yudkin’s hypothesis: sugar is a major dietary culprit in the development of cardiovascular disease

This study says that eating too much sugar, especially fructose, can make your liver create more fat, raise bad blood fats, and cause body-wide inflammation—which all increase your risk of heart disease. It backs up the claim with lots of scientific research.

Study: Fructose drives de novo lipogenesis affecting metabolic health

This study shows that eating too much fructose (like in sugary drinks) makes the liver create more fat, which can lead to higher blood fats and inflammation — both of which raise your risk of heart disease.