Excessive dietary fructose consumption induces hepatic insulin resistance, increases de novo lipogenesis, and elevates circulating triglycerides, thereby contributing to systemic metabolic dysfunction and increased cardiovascular disease risk.

Study: Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial.

This study found that drinking sodas with fructose or table sugar (which contains fructose) makes the liver produce more fat, while drinking soda with plain sugar (glucose) doesn’t. Since excess liver fat is linked to insulin problems and heart disease, this supports the idea that too much fructose is bad for your metabolism.

Study: Fructose and hepatic insulin resistance

This study shows that eating too much fructose (like in sugary drinks) messes up the liver’s ability to respond to insulin, makes the liver create more fat, and raises fat levels in the blood—exactly what the claim says.

Study: John Yudkin’s hypothesis: sugar is a major dietary culprit in the development of cardiovascular disease

This study says that eating too much sugar, especially fructose, can mess up your liver, make your body less responsive to insulin, increase bad fats in your blood, and raise your risk of heart disease—exactly what the claim says.