Exercise boosted a key signaling protein in blood vessels by 37% in obese mice, which helps improve blood flow.
Scientific Claim
In high-fat diet-induced obese mice, 8 weeks of aerobic exercise was associated with a 37% increase in Akt phosphorylation in the aorta compared to sedentary obese mice.
Original Statement
“aerobic exercise training significantly restored the phosphorylation of these signaling molecules in both the aorta (AMPK, 0.61 ±0.04 vs. 0.38 ±0.01; Akt, 0.81 ±0.08 vs. 0.59 ± 0.03; eNOS, 0.74 ±0.01 vs. 0.34 ±0.01) (Fig. 5A) and PVAT (AMPK, 0.76 ±0.07 vs. 0.22 ±0.01; Akt, 0.87 ±0.04 vs. 0.49 ± 0.02; eNOS, 0.72 ±0.00 vs. 0.52 ±0.02) (Fig. 5B) compared to the HF group.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design is a randomized intervention in mice, but GRADE analysis indicates causation cannot be established for human application, so 'associated with' is appropriate.
Evidence from Studies
Supporting (1)
Aerobic Exercise Attenuates Obesity-Associated Vascular Dysfunction via Restoration of Perivascular Adipose Tissue Homeostasis in Mice