Exercise made a key metabolic regulator in the fat around blood vessels 2.45 times more active in obese mice compared to sedentary mice.
Scientific Claim
In high-fat diet-induced obese mice, 8 weeks of aerobic exercise was associated with a 245% increase in AMP-activated protein kinase phosphorylation in perivascular adipose tissue compared to sedentary obese mice.
Original Statement
“phosphorylation of AMPK (0.22±0.01 vs. 1.00±0.00) in the aorta (Fig. 5A) and PVAT (AMPK, 0.22±0.01 vs. 1.00±0.00; Akt, 0.49±0.02 vs. 1.00±0.00; eNOS, 0.52 ±0.02 vs. 1.00 ±0.00) (Fig. 5B) compared to the C group. However, aerobic exercise training significantly restored the phosphorylation of these signaling molecules in both the aorta (AMPK, 0.61 ±0.04 vs. 0.38 ±0.01; Akt, 0.81 ±0.08 vs. 0.59 ± 0.03; eNOS, 0.74 ±0.01 vs. 0.34 ±0.01) (Fig. 5A) and PVAT (AMPK, 0.76 ±0.07 vs. 0.22 ±0.01; Akt, 0.87 ±0.04 vs. 0.49 ± 0.02; eNOS, 0.72 ±0.00 vs. 0.52 ±0.02) (Fig. 5B) compared to the HF group.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design is a randomized intervention in mice, but GRADE analysis indicates causation cannot be established for human application, so 'associated with' is appropriate.
Evidence from Studies
Supporting (1)
Aerobic Exercise Attenuates Obesity-Associated Vascular Dysfunction via Restoration of Perivascular Adipose Tissue Homeostasis in Mice