Exercise made the fat cells around the blood vessels in obese mice about 4.1% smaller than in mice that didn't exercise.
Scientific Claim
In high-fat diet-induced obese mice, 8 weeks of aerobic exercise was associated with a 4.1% reduction in perivascular adipose tissue adipocyte size compared to sedentary obese mice.
Original Statement
“compared to the C group (187.10 ± 5.38 μm2), the HF group (206.98 ± 1.04 μm2) exhibited a significant increase in lipid droplet content (Fig. 2B and C). In high-fat diet-fed mice, aerobic exercise training (HF+E, 198.40 ±1.45 μm2) significantly reduced PVAT adipocyte size compared to the HF group (Fig. 2B and C).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design is a randomized intervention in mice, but GRADE analysis indicates causation cannot be established for human application, so 'associated with' is appropriate.
Evidence from Studies
Supporting (1)
Aerobic Exercise Attenuates Obesity-Associated Vascular Dysfunction via Restoration of Perivascular Adipose Tissue Homeostasis in Mice