Obese mice that exercised on a treadmill for 8 weeks weighed about 22.6% less than obese mice that didn't exercise.

Scientific Claim

In high-fat diet-induced obese mice, 8 weeks of aerobic exercise was associated with a 22.6% reduction in body weight compared to sedentary obese mice.

Original Statement

“body weight... HF group (37.04 ±0.16 g) vs HF+E (28.68 ±0.06 g)”

From study:Aerobic Exercise Attenuates Obesity-Associated Vascular Dysfunction via Restoration of Perivascular Adipose Tissue Homeostasis in Mice

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design is a randomized intervention in mice, but GRADE analysis indicates causation cannot be established for human application, so 'associated with' is appropriate.

Evidence from Studies

Supporting (1)

Aerobic Exercise Attenuates Obesity-Associated Vascular Dysfunction via Restoration of Perivascular Adipose Tissue Homeostasis in Mice

Randomized Controlled Trial

Animal

2025 Jul

Contradicting (0)

No contradicting evidence found

Source Study

Aerobic Exercise Attenuates Obesity-Associated Vascular Dysfunction via Restoration of Perivascular Adipose Tissue Homeostasis in Mice

Score: 14

DOI: 10.5213/inj.2550142.071

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