When obese mice exercised, their blood vessels relaxed 19% better in response to a chemical that normally makes them widen, especially when the surrounding fat tissue was present.
Scientific Claim
In high-fat diet-induced obese mice, 8 weeks of aerobic exercise was associated with a 19.21 percentage point increase in endothelium-dependent relaxation at 10^-5 M acetylcholine in aortic rings with intact perivascular adipose tissue compared to sedentary obese mice.
Original Statement
“The HF group exhibited significantly reduced EDR in response to 10 –5 M acetylcholine compared to the C group, both with PVAT (40.10±0.58 vs. 98.94±0.40) and without PVAT (47.92±0.44 vs. 96.37±0.13) (Fig. 3A and B). However, aerobic exercise training significantly improved EDR in the aorta compared to the HF group, both with (59.31 ±0.71 vs. 40.10 ±0.58) and without PVAT (65.27 ±1.32 vs. 47.92 ± 0.44) (Fig. 3A and B).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design is a randomized intervention in mice, but GRADE analysis indicates causation cannot be established for human application, so 'associated with' is appropriate.
Evidence from Studies
Supporting (1)
Aerobic Exercise Attenuates Obesity-Associated Vascular Dysfunction via Restoration of Perivascular Adipose Tissue Homeostasis in Mice