Exercise increased the activity of a protein that helps blood vessels relax by more than double in the blood vessels of obese mice compared to sedentary mice.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study design is a randomized intervention in mice, but GRADE analysis indicates causation cannot be established for human application, so 'associated with' is appropriate.

Evidence from Studies

Supporting (1)

Aerobic Exercise Attenuates Obesity-Associated Vascular Dysfunction via Restoration of Perivascular Adipose Tissue Homeostasis in Mice

Randomized Controlled Trial

Animal

2025 Jul

Contradicting (0)

No contradicting evidence found

Source Study

Aerobic Exercise Attenuates Obesity-Associated Vascular Dysfunction via Restoration of Perivascular Adipose Tissue Homeostasis in Mice

Score: 14

DOI: 10.5213/inj.2550142.071

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