Exercise boosted levels of a protective anti-inflammatory protein in the blood vessels of obese mice by nearly five times compared to mice that didn't exercise.
Scientific Claim
In high-fat diet-induced obese mice, 8 weeks of aerobic exercise was associated with a 460% increase in adiponectin mRNA expression in the aorta compared to sedentary obese mice.
Original Statement
“aerobic exercise training significantly reduced proinflammatory cytokine expression (TNF-α, 12.98 ±2.20 vs. 35.91 ±1.92) and increased anti-inflammatory adipokine mRNA levels (adipokine, 0.05±0.01 vs. 0.28±0.05) in both the aorta (Fig. 4A–F) and PVAT (Fig. 4G–L), compared to the HF group.”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study design is a randomized intervention in mice, but GRADE analysis indicates causation cannot be established for human application, so 'associated with' is appropriate.
Evidence from Studies
Supporting (1)
Aerobic Exercise Attenuates Obesity-Associated Vascular Dysfunction via Restoration of Perivascular Adipose Tissue Homeostasis in Mice