Fat around the organs dumps fat and inflammatory signals straight into the liver through a special blood pipe, where they can mess with liver cells and immune cells.

Fat around the organs sends out fat molecules and inflammatory signals directly into the liver through a major blood vessel.

Visceral adipose tissue releases bioactive molecules directly into the portal venous system, exposing the liver to elevated concentrations of free fatty acids and inflammatory cytokines.

Fat around the organs sends out chemicals that talk to liver cells and immune cells inside the liver.

Visceral adipose tissue is metabolically active and secretes pro-inflammatory cytokines that impair insulin signaling in liver, muscle, and brain tissues.

When too many fat molecules and inflammatory signals from belly fat reach the liver, it becomes less responsive to insulin.