In people with type 2 diabetes and kidney disease, a weekly injection of semaglutide at 1.0 mg slows the rate at which kidney function declines by 1.16 mL/min/1.73m² per year compared to no...
Mechanism
Synthesis from 1 study
Semaglutide helps the kidneys filter blood more gently by relaxing tiny blood vessels inside them and helping the body remove extra salt and water. This lowers the pressure inside the filters, which protects them from damage over time and slows how fast kidney function declines.
Most probable mechanism
Semaglutide helps the kidneys work more gently by making blood vessels inside the filtering units relax and by helping the body get rid of extra salt and water, which reduces the pressure inside the filters and slows down damage over time.
Semaglutide activates GLP-1 receptors on renal vascular smooth muscle and tubular epithelial cells, leading to vasodilation of afferent arterioles and reduced glomerular capillary pressure.
Increased sodium excretion in the proximal tubule reduces intravascular volume and downstream glomerular filtration pressure.
Lower intraglomerular pressure decreases mechanical stress on podocytes and glomerular basement membrane, reducing structural damage and slowing eGFR decline.
Evidence from Studies
Supporting (1)
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Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes.
Contradicting (0)
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Gold Standard Evidence Needed
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