In people with type 2 diabetes and kidney disease, the medication semaglutide slows the decline in kidney function by about 1.2 mL/min/1.73m² per year compared to a placebo, as measured by standard...
Mechanism
Synthesis from 1 study
Semaglutide helps the kidneys by lowering the pressure inside their filtering units and reducing the buildup of sugar and fat in kidney tissue. This makes the kidneys work less hard and slows down the damage that leads to loss of function over time.
Most probable mechanism
Semaglutide helps the kidneys work more gently by lowering the pressure inside the filtering units and reducing the amount of sugar and fat that leaks into kidney tissue, which prevents damage over time.
Semaglutide activates GLP-1 receptors in the renal vasculature and tubules, leading to afferent arteriolar vasoconstriction and reduced intraglomerular pressure
Reduced intraglomerular pressure decreases mechanical stress on glomerular capillaries and podocytes
Improved glycemic control and reduced lipotoxicity lower metabolic stress on proximal tubule cells
Reduced hemodynamic and metabolic stress decreases tubulointerstitial inflammation and fibrosis, slowing eGFR decline
Evidence from Studies
Supporting (1)
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Contradicting (0)
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