Fructose creates uric acid, which harms blood vessels and makes kidneys hold onto salt.

“The third pathway involves fructose which is metabolized almost entirely in the liver. When fructose is broken down it generates uric acid as a byproduct. Elevated uric acid has been shown in multiple studies to impair endothelial function meaning it reduces nitric oxide availability and prevents arteries from relaxing properly. It also increases renal sodium reabsorption directly independent of insulin.”