In mice with insulin resistance, insulin treatment caused a significant rise in the anion gap (a measure of acid in the blood), suggesting the blood became more acidic.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study measured anion gap levels and found a significant increase. The verb 'was associated with' appropriately reflects the observational data without implying causation.

Evidence from Studies

Supporting (1)

Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Cohort Study

Animal

2018 Sep 22

Contradicting (0)

No contradicting evidence found

Source Study

Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Score: 13

DOI: 10.3390/ijms19102880

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