In mice with insulin resistance, insulin treatment caused a significant rise in the anion gap (a measure of acid in the blood), suggesting the blood became more acidic.

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Supporting (1)

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Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Cohort Study

Animal

2018 Sep 22

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No contradicting evidence found

Source Study

Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Score: 13

DOI: 10.3390/ijms19102880

Similar Assertions

In mice with insulin resistance, insulin treatment made the blood slightly more acidic, as shown by a drop in pH from 7.24 to 7.11.

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In mice with insulin resistance, long-term insulin treatment raised blood sodium levels by about 5 units.

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In mice with insulin resistance, insulin treatment caused a small, temporary rise in systolic blood pressure (about 5 mm Hg) in the first week, but blood pressure returned to normal levels after that.

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In mice with insulin resistance, insulin treatment lowered blood urea nitrogen levels by about two-thirds, which may indicate changes in kidney function or diet.

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