In mice with insulin resistance, insulin treatment caused a significant rise in the anion gap (a measure of acid in the blood), suggesting the blood became more acidic.

Scientific Claim

Chronic insulin infusion in TALLYHO/Jng mice was associated with an increase in anion gap from 3.25 to 14.0 mM after 14 days of treatment, indicating relative metabolic acidosis.

Original Statement

“AnGap (mM) 3.25 ± 1.73 14.0± 3.8 * 8.64 ± 1.15 0.02”

From study:Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study measured anion gap levels and found a significant increase. The verb 'was associated with' appropriately reflects the observational data without implying causation.

Evidence from Studies

Supporting (1)

Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Cohort Study

Animal

2018 Sep 22

Contradicting (0)

No contradicting evidence found

Source Study

Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Score: 13

DOI: 10.3390/ijms19102880

Similar Assertions

In mice with insulin resistance, insulin treatment made the blood slightly more acidic, as shown by a drop in pH from 7.24 to 7.11.

85%

In mice with insulin resistance, long-term insulin treatment raised blood sodium levels by about 5 units.

81%

In mice with insulin resistance, insulin treatment caused a small, temporary rise in systolic blood pressure (about 5 mm Hg) in the first week, but blood pressure returned to normal levels after that.

73%

In mice with insulin resistance, insulin treatment lowered blood urea nitrogen levels by about two-thirds, which may indicate changes in kidney function or diet.

73%