In mice with insulin resistance, insulin treatment made the blood slightly more acidic, as shown by a drop in pH from 7.24 to 7.11.

Scientific Claim

Chronic insulin infusion in TALLYHO/Jng mice was associated with a decrease in blood pH from 7.24 to 7.11 after 14 days of treatment.

Original Statement

“pH(−log10 [H+]) 7.24 ± 0.02 7.11 ± 0.05 * 7.19 ± 0.01 0.027”

From study:Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study measured blood pH and found a significant decrease. The verb 'was associated with' appropriately reflects the observational data without implying causation.

Evidence from Studies

Supporting (1)

Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Cohort Study

Animal

2018 Sep 22

Contradicting (0)

No contradicting evidence found

Source Study

Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Score: 13

DOI: 10.3390/ijms19102880

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