In mice with insulin resistance, insulin treatment caused a small, temporary rise in systolic blood pressure (about 5 mm Hg) in the first week, but blood pressure returned to normal levels after that.

Scientific Claim

Chronic insulin infusion in TALLYHO/Jng mice was associated with a transient increase in systolic blood pressure of approximately 5 mm Hg during the first week of treatment, with no significant long-term changes in mean arterial pressure over 14 days.

Original Statement

“Systolic BP and heart rate were slightly (~5 mm Hg) higher in insulin-infused versus control mice.”

From study:Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study measured blood pressure changes over time and found a transient increase. The verb 'was associated with' correctly describes the observed correlation without implying causation.

Evidence from Studies

Supporting (1)

Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Cohort Study

Animal

2018 Sep 22

Contradicting (0)

No contradicting evidence found

Source Study

Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Score: 13

DOI: 10.3390/ijms19102880

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