In mice with insulin resistance, long-term insulin treatment raised blood sodium levels by about 5 units.

Scientific Claim

Chronic insulin infusion in TALLYHO/Jng mice was associated with an increase in blood sodium concentration from 144 to 149 mM after 14 days of treatment.

Original Statement

“Na+ (mM) 144 ± 0.7 149 ± 1.9 * 146 ± 0.6 0.030”

From study:Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The study measured sodium levels in treated vs control mice, showing a significant difference. The verb 'was associated with' correctly describes the observed correlation without implying causation.

Evidence from Studies

Supporting (1)

Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Cohort Study

Animal

2018 Sep 22

Contradicting (0)

No contradicting evidence found

Source Study

Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting Greater Endothelial NO Synthase Activity in Mice

Score: 13

DOI: 10.3390/ijms19102880

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