In mice with type 2 diabetes, mulberry leaf water extract is linked to lower levels of certain blood molecules involved in metabolism and inflammation, as well as increased activity of enzymes that...
Mechanism
Synthesis from 1 study
This plant extract fixes the balance of gut bacteria, which stops harmful toxins from leaking into the bloodstream. That tells the liver and gut to break down more of the body’s natural stress chemicals, helping the body manage sugar and fat more effectively.
Most probable mechanism
Good bacteria in the gut are boosted by a natural plant extract, which stops bad bacteria from leaking harmful chemicals into the blood. This lowers inflammation and tells the liver and gut to break down more of the body’s natural stress chemicals, which in turn helps the body use sugar and fat better.
A plant-derived compound alters the composition of gut bacteria, increasing beneficial strains and reducing populations that produce lipopolysaccharide.
Reduced lipopolysaccharide production decreases its translocation across the intestinal barrier, lowering systemic endotoxin levels.
Lower systemic endotoxin reduces chronic inflammation and restores integrity of intestinal tight junctions.
Decreased inflammation and microbial signals trigger increased expression of enzymes that break down endocannabinoids in the liver and ileum.
Expression of enzymes that synthesize endocannabinoids is suppressed, further reducing their production.
Net reduction in endocannabinoid levels decreases overactivation of cannabinoid receptors linked to insulin resistance and fat storage.
Improved metabolic signaling enhances glucose uptake and lipid metabolism, reducing hyperglycemia and dyslipidemia.
Evidence from Studies
Supporting (1)
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