Can a plant extract fix a diabetic gut?
Mulberry (Morus alba L.) leaf water extract attenuates type 2 diabetes mellitus by regulating gut microbiota dysbiosis, lipopolysaccharide elevation and endocannabinoid system disorder.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave diabetic mice a tea made from mulberry leaves and saw their gut got healthier, their blood sugar improved, and harmful chemicals in their blood went down.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
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Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists gave diabetic mice a tea made from mulberry leaves and saw their gut got healthier, their blood sugar improved, and harmful chemicals in their blood went down.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 512 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Publication
Authors
Du Y, Zhang R, Zheng XX, Zhao YL, Chen YL, Ji S, Guo MZ, Tang DQ
Related Content
Claims (6)
When the lining of the intestines becomes less effective at blocking substances from passing into the bloodstream, it leads to higher levels of inflammatory markers in the body.
In mice with type 2 diabetes, consuming mulberry leaf water extract is linked to changes in the levels of certain gut bacteria, and these changes are related to lower levels of two blood compounds called LPS and endocannabinoids.
In mice with type 2 diabetes, a water extract from mulberry leaves is linked to higher levels of two enzymes in the liver and small intestine that break down endocannabinoids, potentially leading to lower levels of these signaling molecules.
In mice with type 2 diabetes, mulberry leaf water extract is linked to lower levels of certain blood molecules involved in metabolism and inflammation, as well as increased activity of enzymes that regulate these molecules in the gut and liver.
In diabetic mice, the metabolic benefits of mulberry leaf water extract require the presence of gut microbes, as mice without these microbes show reduced improvements in key metabolic and barrier markers.