Taking 7 mg of lycosome-formulated lycopene every day for 30 days is linked to a 5-times reduction in oxidized LDL levels in people with coronary vascular disease. Lactolycopene, another form of lycopene, does not produce this effect.
See the scientific wording
Supplementation with lycosome-formulated lycopene at 7 mg daily for 30 days is associated with a fivefold reduction in oxidized LDL levels in patients with coronary vascular disease, while lactolycopene shows no significant effect.
Very strong evidence
Randomized trialsOne moderate-quality study supports this claim, so treat this as an early signal rather than settled science.
What the research says
1 study reviewedSupporting (1)
Randomized Controlled TrialHuman2018
The study gave people with heart disease a special lycopene supplement and found that it lowered a harmful form of cholesterol by five times, just as the claim says.
Contradicting (0)
No contradicting studies found yet
That doesn't mean it's settled — it just means no study has tested the opposite.
Quality-weighted scoring: we follow the GRADE framework — each study is rated High, Moderate, Low, or Very Low based on study design, methodology rigor, and risk of bias. A single high-quality RCT can outweigh several weaker observational studies.
Scores reflect study quality, not just count.
The lycosome formulation wraps lycopene in a special coating that helps it get absorbed into the blood much better than regular lycopene. Once in the blood, lycopene acts like a sponge, soaking up harmful free radicals that would otherwise damage LDL cholesterol, turning it into oxidized LDL. By neutralizing these free radicals, lycopene prevents LDL oxidation, leading to a fivefold drop in oxidized LDL levels.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting study
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Taking 7 mg of lycosome-formulated lycopene every day for 30 days is linked to a 5-times reduction in oxidized LDL levels in people with coronary vascular disease. Lactolycopene, another form of lycopene, does not produce this effect.
Mechanism
1 studyThe special lycosome coating helps lycopene get into the blood much better. Once there, lycopene mops up harmful free radicals that would otherwise damage LDL cholesterol, lowering oxidized LDL by five times.
The lycosome formulation wraps lycopene in a special coating that helps it get absorbed into the blood much better than regular lycopene. Once in the blood, lycopene acts like a sponge, soaking up harmful free radicals that would otherwise damage LDL cholesterol, turning it into oxidized LDL. By neutralizing these free radicals, lycopene prevents LDL oxidation, leading to a fivefold drop in oxidized LDL levels.
Lycosome formulation protects lycopene from degradation in the gut and enhances its absorption into the bloodstream, significantly increasing serum lycopene levels.
Increased circulating lycopene acts as a potent antioxidant, scavenging free radicals and reducing oxidative stress, specifically preventing the oxidation of LDL cholesterol.
Reduced oxidative stress lowers the amount of oxidized LDL in the blood, as directly measured by a fivefold reduction in oxidized LDL levels.
Evidence from Studies
Supporting (1)
Community contributions welcome
Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease
The study gave people with heart disease a special lycopene supplement and found that it lowered a harmful form of cholesterol by five times, just as the claim says.
Contradicting (0)
Community contributions welcome
Score Breakdown
No multi-axis breakdown available yet. The overall Pro / Against score above is the best signal.
- No clinical evidence is available; the score reflects mechanistic plausibility only.
What Would Prove This
Per GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this claim, ordered from strongest to weakest.
Systematic Review and Meta-Analysis: Lycosome-formulated Lycopene vs Placebo and Lactolycopene for Oxidized LDL Reduction in Coronary Vascular Disease
Comprehensive search for randomized controlled trials and cohort studies comparing lycosome-formulated lycopene (7 mg/day for 30 days) to placebo or lactolycopene on oxidized LDL levels in adults with coronary vascular disease, with meta-analysis of pooled data.
Double-Blind RCT: Lycosome-formulated Lycopene vs Placebo and Lactolycopene on Oxidized LDL in Coronary Vascular Disease Patients
Double-blind, parallel-group RCT enrolling patients with coronary vascular disease, randomized to receive lycosome-formulated lycopene (7 mg/day), lactolycopene (7 mg/day), or placebo for 30 days, with measurement of oxidized LDL at baseline and day 30.
Prospective Cohort Study: Lycosome-formulated Lycopene Supplement Use and Oxidized LDL Trajectories in Coronary Vascular Disease
Prospective cohort of coronary vascular disease patients, categorized by self-selected lycosome-formulated lycopene use, lactolycopene use, or no supplement, followed for 30 days with serial oxidized LDL measurements, adjusting for confounders.
Case-Control Study: Lycosome-formulated Lycopene Supplementation History in Coronary Vascular Disease Patients with High vs Low Oxidized LDL
Select coronary vascular disease patients with oxidized LDL in lowest quartile (cases) and highest quartile (controls); retrospectively compare lycosome-formulated lycopene, lactolycopene, and other supplement use via interviews or records.