Resting longer between sets lets you lift more total weight, which makes muscles grow bigger.
Evidence from Studies
Supporting (1)
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Increased Neuromuscular Activity, Force Output, and Resistance Exercise Volume When Using 5-Minute Compared with 2-Minute Rest Intervals Between the Sets
This study found that taking longer breaks (5 minutes) between weightlifting sets lets you lift more total weight and feel less tired than taking short breaks (2 minutes), which means you can work your muscles harder — and that’s how muscles grow bigger.
Contradicting (2)
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Give it a rest: a systematic review with Bayesian meta-analysis on the effect of inter-set rest interval duration on muscle hypertrophy
The study found that resting longer between sets doesn’t make your muscles grow much more than resting briefly — and it’s not because you’re lifting more weight overall. So, the idea that longer rests boost muscle growth by letting you lift more doesn’t hold up.
The study found that whether you rest 20 seconds or 2 minutes between sets, you get the same muscle growth as long as you do the same total amount of work — so longer rests don’t magically make you bigger.