Insulin induces nitric oxide-mediated vasodilation in skeletal muscle, which increases perfusion and enhances the delivery of creatine to the sarcolemma where SLC6A8 transporters are located.

Study: Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release.

The study shows insulin helps widen blood vessels in muscle by increasing nitric oxide, which boosts blood flow—just like the claim says. But it doesn’t test whether this actually helps deliver more creatine to muscle cells.

Study: Insulin-mediated muscle microvascular perfusion and its phenotypic predictors in humans

The study shows that insulin increases blood flow in muscle, which helps deliver nutrients. This supports the idea that insulin improves delivery of substances like creatine, even if it doesn’t prove exactly how or where.

Study: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes.

The study shows that insulin helps widen blood vessels in muscle using nitric oxide, which improves blood flow—this supports part of the claim. It doesn’t test creatine directly, but the blood flow part is backed by the evidence.

Study: 109-OR: GIP Acutely Blunts Insulin- and GLP-1–Induced Muscle Microvascular Perfusion

The study shows insulin increases blood flow to muscles, which supports the idea that it helps deliver substances like creatine. However, it doesn’t directly test creatine or its transporters.