Fasting creates harmful stress in your cells, but methylene blue helps clean it up without stopping your body’s natural adaptation.

This study shows methylene blue can reduce harmful stress in fat tissue around the heart, but it didn’t test fasting or whether the body’s natural healing responses are preserved—so it doesn’t prove the claim.

The study found that methylene blue sometimes makes more harmful molecules (ROS) in heart cells, not less, and it was tested in diabetic rats, not people who are fasting—so it doesn’t support the claim that it helps during fasting without disrupting beneficial stress responses.

This study found that methylene blue hurts fish by increasing harmful stress in their bodies, not helping them like the claim says. It doesn’t support the idea that it protects during fasting.