Fasting creates harmful stress in your cells, but methylene blue helps clean it up without stopping your body’s natural adaptation.
Scientific Claim
Methylene blue selectively mitigates excessive oxidative stress during fasting while preserving adaptive hormetic responses.
Original Statement
“When you're fasting, you have a high amount of oxidative stress. So, this is where methylene blue could come in play. It's not just going to help you from a potential appetite suppressant side, but it's going to help you out from an overall aspect of just neutralizing some of the additional like stress that might come above and beyond.”
Context Details
Domain
pharmacology
Population
human
Subject
methylene blue
Action
selectively mitigates
Target
excessive oxidative stress during fasting
Intervention Details
Evidence from Studies
Supporting (0)
Contradicting (3)
Methylene blue reduces monoamine oxidase expression and oxidative stress in human cardiovascular adipose tissue
This study shows methylene blue can reduce harmful stress in fat tissue around the heart, but it didn’t test fasting or whether the body’s natural healing responses are preserved—so it doesn’t prove the claim.
The study found that methylene blue sometimes makes more harmful molecules (ROS) in heart cells, not less, and it was tested in diabetic rats, not people who are fasting—so it doesn’t support the claim that it helps during fasting without disrupting beneficial stress responses.
This study found that methylene blue hurts fish by increasing harmful stress in their bodies, not helping them like the claim says. It doesn’t support the idea that it protects during fasting.