How a blue dye helps calm fat around the heart
Methylene blue reduces monoamine oxidase expression and oxidative stress in human cardiovascular adipose tissue
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
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Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 533 / 44
Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Publication
Journal
Molecular and Cellular Biochemistry
Year
2024
Authors
Oana M Aburel, Laurentiu Braescu, Darius G. Buriman, Adrian P. Merce, A. Bînă, C. Borza, Cristian Mornoș, A. Sturza, D. Muntean
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Claims (10)
In the fat around the heart and blood vessels of heart failure patients, the MAO-A enzyme is much more common than the MAO-B enzyme.
When fat tissue around the heart and blood vessels was soaked in a blue dye called methylene blue for a day in the lab, it made less of a harmful enzyme and produced fewer damaging chemicals, which might help explain how the dye could protect cells.
The blue dye methylene blue cut the amount of a harmful chemical (hydrogen peroxide) in heart and blood vessel fat by about half when tested in the lab.
When the fat tissue was given serotonin (a chemical that MAO-A breaks down), it made more harmful molecules—but adding methylene blue stopped some of that increase.
In the fat around the heart and blood vessels of heart failure patients, a specific enzyme called MAO-A is much more common and makes more harmful chemicals than its cousin MAO-B.