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Strong Support

In the fat around the heart and blood vessels of heart failure patients, the MAO-A enzyme is much more common than the MAO-B enzyme.

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Evidence from Studies

Supporting (1)

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Methylene blue reduces monoamine oxidase expression and oxidative stress in human cardiovascular adipose tissue

Cross-Sectional Study
Human
2025 Apr

Scientists found that in fat around the hearts of heart failure patients, a protein called MAO-A is much more common than MAO-B, and it helps create harmful stress in the tissue.

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No contradicting evidence found

Source Study

Methylene blue reduces monoamine oxidase expression and oxidative stress in human cardiovascular adipose tissue

Score: 33
DOI: 10.1007/s11010-024-05092-z

Similar Assertions

In the fat around the heart and blood vessels of heart failure patients, a specific enzyme called MAO-A is much more common and makes more harmful chemicals than its cousin MAO-B.

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When fat tissue around the heart and blood vessels from heart failure patients was soaked in a small amount of methylene blue for a day, the levels of a specific enzyme (MAO-A) that makes harmful molecules went down.

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When fat tissue around the heart and blood vessels was soaked in a blue dye called methylene blue for a day in the lab, it made less of a harmful enzyme and produced fewer damaging chemicals, which might help explain how the dye could protect cells.

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