Scientists gave male mice a special form of estrogen called 17-alpha-estradiol and found that the mice lost about 20% of their body weight, and they stayed lighter the whole time they were being treated.

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Pro

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Against

Evidence from Studies

Supporting (1)

13

Community contributions welcome

13

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Cohort Study

Animal

2021 May

The study tested the same drug (17-alpha-estradiol) on male mice and found they lost about 20% of their body weight, which is exactly what the claim says happened.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Score: 13

DOI: 10.1111/acel.13328

Similar Assertions

Scientists gave male mice a special form of estrogen and they lost weight, but that weight loss didn't make them live longer - female mice also lost weight but didn't get any lifespan benefit from it.

13

0

87%

A special form of estrogen called 17-alpha-estradiol helped male mice live longer, but female mice given the same amount didn't get any lifespan benefit.

13

0

74%

When scientists gave mice special hormone treatments, the tissue samples from those mice grew bigger and heavier compared to tissue from mice that didn't get the treatment. This shows hormones can make tissues grow more.

11

0

73%