A special form of estrogen called 17-alpha-estradiol helped male mice live longer, but female mice given the same amount didn't get any lifespan benefit.

13

Pro

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Against

Evidence from Studies

Supporting (1)

13

Community contributions welcome

13

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Cohort Study

Animal

2021 May

The study tested the same drug (17-alpha-estradiol) at the same dose (14.4 ppm) as mentioned in the claim. It found significant lifespan extension in male mice but doesn't provide clear data on female mice in this particular study. The claim that benefits were specific to males is consistent with what the study reports.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Score: 13

DOI: 10.1111/acel.13328

Similar Assertions

A special form of estrogen given to mice at a specific dose helped male mice live longer, but didn't have the same effect on female mice.

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13

94%

A special form of estrogen called 17-alpha-estradiol helped male mice live longer when they started taking it in middle age - about 19% longer if started at 16 months old and 11% longer if started at 20 months old. It also increased their maximum lifespan by 7%. But female mice didn't get any lifespan benefit from it at all.

13

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93%

Scientists fed old male mice a special chemical called 17-α-estradiol and found they lived about 19% longer than mice that didn't get the chemical.

13

0

92%

Scientists gave old male mice a special compound called 17-alpha-estradiol in their food starting at 20 months old (roughly equivalent to late middle age in humans), and the mice lived about 11% longer than mice that didn't get the compound.

13

0

92%

Giving male mice a special compound called 17-α-estradiol when they were middle-aged (16 months) helped them live about 7% longer, specifically extending their maximum lifespan.

13

0

91%