A special form of estrogen given to mice at a specific dose helped male mice live longer, but didn't have the same effect on female mice.

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Pro

13

Against

Evidence from Studies

Supporting (0)

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No supporting evidence found

Contradicting (1)

13

Community contributions welcome

13

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Cohort Study

Animal

2021 May

The study tested the same drug (17aE2) at the same dose (14.4 ppm) as the claim mentions, but only reports results for male mice. There's no information in the abstract about what happened to female mice given 17aE2, so we can't tell if the claim about females is true or false.

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Score: 13

DOI: 10.1111/acel.13328

Similar Assertions

A special form of estrogen called 17-alpha-estradiol helped male mice live longer, but female mice given the same amount didn't get any lifespan benefit.

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Giving male mice a special compound called 17-α-estradiol when they were middle-aged (16 months) helped them live about 7% longer, specifically extending their maximum lifespan.

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Scientists fed old male mice a special chemical called 17-α-estradiol and found they lived about 19% longer than mice that didn't get the chemical.

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Scientists gave old male mice a special compound called 17-alpha-estradiol when they were about 1.3 years old, and it helped them live about 19% longer - going from an average of about 2 years to over 2.5 years.

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