Scientists gave male mice a special form of estrogen and they lost weight, but that weight loss didn't make them live longer - female mice also lost weight but didn't get any lifespan benefit from it.

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Against

Evidence from Studies

Supporting (1)

13

Community contributions welcome

13

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Cohort Study

Animal

2021 May

The study tested the same drug (17-alpha-estradiol) at the same dose (14.4 ppm) and confirmed that it reduced body weight by about 20% and extended male mouse lifespan by 19%. The claim about female mice cannot be fully verified from this study, but the main points about weight reduction and male lifespan extension are supported.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

17‐a‐estradiol late in life extends lifespan in aging UM‐HET3 male mice; nicotinamide riboside and three other drugs do not affect lifespan in either sex

Score: 13

DOI: 10.1111/acel.13328

Similar Assertions

Scientists gave male mice a special form of estrogen called 17-alpha-estradiol and found that the mice lost about 20% of their body weight, and they stayed lighter the whole time they were being treated.

13

0

87%

A special form of estrogen called 17-alpha-estradiol helped male mice live longer, but female mice given the same amount didn't get any lifespan benefit.

13

0

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A special form of estrogen given to mice at a specific dose helped male mice live longer, but didn't have the same effect on female mice.

0

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Scientists fed old male mice a special chemical called 17-α-estradiol and found they lived about 19% longer than mice that didn't get the chemical.

13

0

83%

A special form of estrogen called 17-alpha-estradiol helped male mice live longer when they started taking it in middle age - about 19% longer if started at 16 months old and 11% longer if started at 20 months old. It also increased their maximum lifespan by 7%. But female mice didn't get any lifespan benefit from it at all.

13

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83%