Mice that got the supplement had much lower levels of genes involved in fat uptake and storage in their livers compared to mice that didn't get it.
Scientific Claim
N-acetylcysteine supplementation reduced hepatic Cd36 expression by approximately 84% and Mgat1 expression by approximately 98% in male C57BL/6 mice fed a high-fat diet compared to untreated high-fat diet mice, as measured by mRNA levels.
Original Statement
“In contrast, NAC treatment significantly inhibited Pparγ expression, suppressing the induction of its target genes, including Cd36 (84%) and monoacylglycerol O-acyltransferase 1 (Mgat1, 98%).”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study shows an association between NAC and reduced Cd36 and Mgat1 expression in mice, but cannot prove causation due to study design limitations. The phrase 'significantly inhibited' overstates the evidence.
More Accurate Statement
“N-acetylcysteine supplementation was associated with approximately 84% reduction in hepatic Cd36 expression and 98% reduction in Mgat1 expression in male C57BL/6 mice fed a high-fat diet compared to untreated high-fat diet mice, as measured by mRNA levels.”
Evidence from Studies
Supporting (1)
N-acetylcysteine Protects Mice from High Fat Diet-induced Metabolic Disorders