Mice that got the supplement had about half as much body fat as mice that didn't get it, even when both groups ate the same high-fat diet.
Scientific Claim
N-acetylcysteine supplementation reduced fat mass by approximately 55% in male C57BL/6 mice fed a high-fat diet compared to untreated high-fat diet mice, as measured by magnetic resonance imaging.
Original Statement
“Body composition analysis revealed that the NAC treatment largely suppressed the gain of fat mass with an approximately 55% reduction in fat mass compared to that of control animals, irrespective of mice with regular chow or HFD feeding.”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study shows an association between NAC and reduced fat mass in mice, but cannot prove causation due to study design limitations. The phrase 'largely suppressed' overstates the evidence.
More Accurate Statement
“N-acetylcysteine supplementation was associated with approximately 55% reduction in fat mass in male C57BL/6 mice fed a high-fat diet compared to untreated high-fat diet mice, as measured by magnetic resonance imaging.”
Evidence from Studies
Supporting (1)
N-acetylcysteine Protects Mice from High Fat Diet-induced Metabolic Disorders