Mice that got the supplement had less fat buildup in their brown fat compared to mice that didn't get it.
Scientific Claim
N-acetylcysteine supplementation reduced fat deposition in brown adipose tissue of male C57BL/6 mice fed a high-fat diet compared to untreated high-fat diet mice, as measured by H&E staining.
Original Statement
“H&E stained brown adipose tissue (BAT) tissues show that HFD feeding increased fat deposition in brown adipocytes, resulting in BAT whitening. NAC treatment, however, dramatically inhibited adipocyte expansion in both chow- and HFD-fed mice (Fig. 7a).”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study shows an association between NAC and reduced fat deposition in BAT in mice, but cannot prove causation due to study design limitations. The phrase 'dramatically inhibited' overstates the evidence.
More Accurate Statement
“N-acetylcysteine supplementation was associated with reduced fat deposition in brown adipose tissue of male C57BL/6 mice fed a high-fat diet compared to untreated high-fat diet mice, as measured by H&E staining.”
Evidence from Studies
Supporting (1)
N-acetylcysteine Protects Mice from High Fat Diet-induced Metabolic Disorders