The fat cells in mice that got the supplement were about 30% smaller than in mice that didn't get it.
Scientific Claim
N-acetylcysteine supplementation reduced adipocyte size in epididymal and subcutaneous adipose tissue by approximately 30% in male C57BL/6 mice fed a high-fat diet compared to untreated high-fat diet mice.
Original Statement
“H&E staining of adipocytes demonstrate that NAC reduced the size of adipocytes in EWAT and SubWAT in mice fed an HFD, this was further confirmed by quantitative analysis using an imaging system (Fig. 2b–d).”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study shows an association between NAC and reduced adipocyte size in mice, but cannot prove causation due to study design limitations. The claim states a specific percentage reduction (30%) which isn't explicitly stated in the excerpt.
More Accurate Statement
“N-acetylcysteine supplementation was associated with reduced adipocyte size in epididymal and subcutaneous adipose tissue in male C57BL/6 mice fed a high-fat diet compared to untreated high-fat diet mice, as measured by quantitative imaging analysis.”
Evidence from Studies
Supporting (1)
N-acetylcysteine Protects Mice from High Fat Diet-induced Metabolic Disorders