Mice that got the supplement had much lower levels of insulin in their blood compared to mice that didn't get it.
Scientific Claim
N-acetylcysteine supplementation reduced serum insulin levels by approximately 86% in male C57BL/6 mice fed a high-fat diet compared to untreated high-fat diet mice.
Original Statement
“Obesity-associated hyperinsulinemia was strikingly ameliorated by NAC treatment (8.3 μg/l vs. 1.1 μg/l) (Fig. 4d).”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study shows an association between NAC and reduced insulin levels in mice, but cannot prove causation due to study design limitations. The phrase 'strikingly ameliorated' overstates the evidence.
More Accurate Statement
“N-acetylcysteine supplementation was associated with approximately 86% reduction in serum insulin levels in male C57BL/6 mice fed a high-fat diet compared to untreated high-fat diet mice.”
Evidence from Studies
Supporting (1)
N-acetylcysteine Protects Mice from High Fat Diet-induced Metabolic Disorders