Mice that got the supplement were better able to handle sugar in their blood after eating.
Scientific Claim
N-acetylcysteine supplementation improved glucose tolerance in male C57BL/6 mice fed a high-fat diet, as measured by lower blood glucose levels during glucose tolerance tests and reduced area under the curve.
Original Statement
“The results in Fig. 4a show that HFD feeding induced higher fasting glucose levels compared to that of animals fed a regular chow, and exhibited a much slower clearance rate of injected glucose. NCA treated mice exhibited a much higher clearance rate, which was better represented using the calculated area under the curve (AUC, Fig. 4b).”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study shows an association between NAC and improved glucose tolerance in mice, but cannot prove causation due to study design limitations. The phrase 'improved glucose tolerance' is somewhat definitive for this study design.
More Accurate Statement
“N-acetylcysteine supplementation was associated with improved glucose tolerance in male C57BL/6 mice fed a high-fat diet, as measured by lower blood glucose levels during glucose tolerance tests and reduced area under the curve.”
Evidence from Studies
Supporting (1)
N-acetylcysteine Protects Mice from High Fat Diet-induced Metabolic Disorders