Mice that got the supplement had much lower levels of fat and cholesterol in their livers compared to mice that didn't get it.
Scientific Claim
N-acetylcysteine supplementation reduced hepatic triglyceride and cholesterol levels by approximately 50% in male C57BL/6 mice fed a high-fat diet compared to untreated high-fat diet mice.
Original Statement
“Blockage of hepatic lipid accumulation by NAC was further confirmed by measurements of hepatic triglyceride and cholesterol levels (Fig. 5b).”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study shows an association between NAC and reduced liver fat in mice, but cannot prove causation due to study design limitations. The claim states a specific 50% reduction which isn't explicitly stated in the excerpt.
More Accurate Statement
“N-acetylcysteine supplementation was associated with reduced hepatic triglyceride and cholesterol levels in male C57BL/6 mice fed a high-fat diet compared to untreated high-fat diet mice.”
Evidence from Studies
Supporting (1)
N-acetylcysteine Protects Mice from High Fat Diet-induced Metabolic Disorders