Mice that got the supplement were more responsive to insulin compared to mice that didn't get it.
Scientific Claim
N-acetylcysteine supplementation improved insulin sensitivity in male C57BL/6 mice fed a high-fat diet, as measured by insulin tolerance tests and serum insulin levels.
Original Statement
“NAC-treated mice also showed a rapid response to insulin administration (Fig. 4c). Accordingly, obesity-associated hyperinsulinemia was strikingly ameliorated by NAC treatment (8.3 μg/l vs. 1.1 μg/l) (Fig. 4d).”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study shows an association between NAC and improved insulin sensitivity in mice, but cannot prove causation due to study design limitations. The phrase 'improved insulin sensitivity' is somewhat definitive for this study design.
More Accurate Statement
“N-acetylcysteine supplementation was associated with improved insulin sensitivity in male C57BL/6 mice fed a high-fat diet, as measured by insulin tolerance tests and serum insulin levels.”
Evidence from Studies
Supporting (1)
N-acetylcysteine Protects Mice from High Fat Diet-induced Metabolic Disorders