Mice that got the supplement had higher levels of a hormone that helps regulate metabolism in their fat tissue.
Scientific Claim
N-acetylcysteine supplementation increased adiponectin gene expression by approximately 2-fold in white adipose tissue of male C57BL/6 mice fed a high-fat diet compared to untreated high-fat diet mice.
Original Statement
“Adiponectin mRNA level was significantly lower in HFD fed obese mice, whereas NAC evidently promoted adiponectin gene expression (Fig. 3f).”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study shows an association between NAC and increased adiponectin expression in mice, but cannot prove causation due to study design limitations. The claim states a specific 2-fold increase which isn't explicitly stated in the excerpt.
More Accurate Statement
“N-acetylcysteine supplementation was associated with increased adiponectin gene expression in white adipose tissue of male C57BL/6 mice fed a high-fat diet compared to untreated high-fat diet mice.”
Evidence from Studies
Supporting (1)
N-acetylcysteine Protects Mice from High Fat Diet-induced Metabolic Disorders