Mice that got the supplement had higher levels of genes that help burn fat in their livers compared to mice that didn't get it.
Scientific Claim
N-acetylcysteine supplementation increased expression of Cpt1a and Cpt1b genes by approximately 50% in liver of male C57BL/6 mice fed a high-fat diet compared to untreated high-fat diet mice, as measured by mRNA levels.
Original Statement
“NAC treatment also increased mRNA levels of genes involved in fatty acid metabolism including carnitine palmitoyltransferase I (Cpt1a, Cpt1b).”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study shows an association between NAC and increased Cpt1a and Cpt1b expression in mice, but cannot prove causation due to study design limitations. The claim states a specific 50% increase which isn't explicitly stated in the excerpt.
More Accurate Statement
“N-acetylcysteine supplementation was associated with increased expression of Cpt1a and Cpt1b genes in liver of male C57BL/6 mice fed a high-fat diet compared to untreated high-fat diet mice, as measured by mRNA levels.”
Evidence from Studies
Supporting (1)
N-acetylcysteine Protects Mice from High Fat Diet-induced Metabolic Disorders