correlational
Analysis v1
33
0
MOTS-c helps diabetic mice process sugar better and reduces aging signs in their pancreas cells.
Scientific Claim
MOTS-c treatment in S961-treated C57BL/6 mice is associated with improved glucose tolerance and reduced senescence markers.
Original Statement
“MOTS-c administration significantly improved glucose tolerance (Fig. 3m,n) and lowered β-gal-stained cells compared with those treated with scrambled peptide (Fig. 3o).”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study used 'improved' and 'lowered' which imply causation, but the design lacks randomization/blinding confirmation. Corrected to 'associated with' to reflect observational association.
Evidence from Studies
Supporting (1)
33
33
Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes
Randomized Controlled Trial
Human
2025 AugContradicting (0)
0
No contradicting evidence found