Old mice that got MOTS-c injections responded to insulin just as well as young mice, meaning the peptide might fix the insulin resistance that comes with aging.

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Evidence from Studies

Supporting (1)

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The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Randomized Controlled Trial

Animal

2015 Mar 3

Scientists gave a special protein called MOTS-c to old mice, and it helped their bodies respond better to insulin again—just like in young mice—meaning it might fix age-related metabolism problems.

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Source Study

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

Score: 13

DOI: 10.1016/j.cmet.2015.02.009

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