Back to "MOTS-c levels decreased with age in 60- ..."
Strong Support
descriptive
Analysis v1
History

Older mice have less MOTS-c in their pancreatic cells than younger mice.

33
Pro
0
Against

Evidence from Studies

Supporting (1)

33

Community contributions welcome

33

Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes

Randomized Controlled Trial
Human & Animal & In Vitro
2025 Aug

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Sign up to see full verdict

Source Study

Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes

Score: 33
DOI: 10.1038/s12276-025-01521-1

Similar Assertions

When stressed, older mice's pancreatic cells have less MOTS-c than younger mice's cells.

33
0
94%

Giving MOTS-c to diabetic mice helps reduce signs of aging in their pancreatic cells.

33
0
83%

Old mice that got MOTS-c injections responded to insulin just as well as young mice, meaning the peptide might fix the insulin resistance that comes with aging.

13
0
76%

MOTS-c helps turn down genes linked to cell aging in pancreatic cells.

33
0
74%

MOTS-c helps pancreatic cells produce more energy through their mitochondria.

33
0
73%