Analysis Version
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Back to Study: Mitochondrial-encoded peptide MOTS-c prevents panc...
descriptive
Analysis v1
33
Pro
0
Against

Older mice have less MOTS-c in their pancreatic cells than younger mice.

Scientific Claim

MOTS-c levels in pancreatic islet cells are lower in aged mice compared to young mice.

Original Statement

“MOTS-c levels decreased with age in 60- and 90-week-old C57BL/6 mice compared with 12-week-old mice (Fig. 1b).”

From study:Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

association

Can only show association/correlation

Assessment Explanation

The claim describes a correlation observed in the data without causal language. The study design (comparing age groups in mice) supports this association.

Evidence from Studies

Supporting (1)

33
33

Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes

Randomized Controlled Trial
Human
2025 Aug

Contradicting (0)

0
No contradicting evidence found

Source Study

Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes

Score: 33
DOI: 10.1038/s12276-025-01521-1

Similar Assertions

When stressed, older mice's pancreatic cells have less MOTS-c than younger mice's cells.

33
0
94%

Giving MOTS-c to diabetic mice helps reduce signs of aging in their pancreatic cells.

33
0
83%

Old mice that got MOTS-c injections responded to insulin just as well as young mice, meaning the peptide might fix the insulin resistance that comes with aging.

13
0
76%

MOTS-c helps turn down genes linked to cell aging in pancreatic cells.

33
0
74%

MOTS-c helps pancreatic cells produce more energy through their mitochondria.

33
0
73%