Giving MOTS-c to diabetic mice helps reduce signs of aging in their pancreatic cells.
Scientific Claim
Systemic MOTS-c treatment in NOD mice is associated with reduced pancreatic islet senescence markers.
Original Statement
“MOTS-c treatment, whether alone or in combination with exendin-4, reduced the frequency of γ-H2AX expression compared with the scrambled peptide-treated control group in insulin-positive pancreatic islet cells (Fig. 2f).”
Evidence Quality Assessment
Claim Status
overstated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study used 'reduced' which implies causation, but the design lacks randomization/blinding confirmation. Corrected to 'associated with' to reflect observational association.
Evidence from Studies
Supporting (1)
Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes